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Literature summary for 3.4.22.52 extracted from

  • Kim, D.S.; Han, B.G.; Park, K.S.; Lee, B.I.; Kim, S.Y.; Bae, C.D.
    I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway (2010), Biochem. Biophys. Res. Commun., 399, 300-306.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
I-kappaBalpha polymer + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
I-kappaBalpha polymer + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
mu-calpain
-
Homo sapiens

General Information

General Information Comment Organism
physiological function mu-calpain proteasome-dependent I-kappaBalpha polymer degradation may contribute to cancer progression through constitutive nulear factor-kappaB activation Homo sapiens