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Literature summary for 3.4.22.52 extracted from

  • Chandramohanadas, R.; Davis, P.H.; Beiting, D.P.; Harbut, M.B.; Darling, C.; Velmourougane, G.; Lee, M.Y.; Greer, P.A.; Roos, D.S.; Greenbaum, D.C.
    Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells (2009), Science, 324, 794-797.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
calpastatin highly specific calpain inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
about 80000 Da, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
U2-OS cell
-
Homo sapiens
-

General Information

General Information Comment Organism
malfunction immunodepletion or inhibition of calpain-1 in hypotonically lysed and resealed erythrocytes prevents the escape of Plasmodium falciparum parasites. Similarly, efficient egress of Tooplasma gondii from mammalian fibroblasts is blocked by either small interfering RNA-mediated suppression or genetic deletion of calpain activity Homo sapiens