Application | Comment | Organism |
---|---|---|
medicine | calpain and calpain inhibition is a therapeutic tool in Parkinsons disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MDL-28710 | complete inhibition at 100 nM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, dysfunctional mitochondria increase cytosolic calcium, thereby inducing calpain activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NT2-Rho0 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-LLY-7-amido-4-fluoromethylcoumarin + H2O | - |
Homo sapiens | acetyl-LLY + 7-amino-4-fluoromethylcoumarin | - |
? | |
alpha-synuclein + H2O | - |
Homo sapiens | 145000 DA fragment + 150 Da fragment + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calpain 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | compared to control cybrids, Parkonsins disease cybrids reveal a significant increase in calpain activity | up |
General Information | Comment | Organism |
---|---|---|
malfunction | calpain-1 overactivation in mitochondrial-deficient cells promotes caspase-3 activation, calpain inhibition decreases alpha-synuclein oligomerization | Homo sapiens |