Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calpain inhibitor-III | - |
Mus musculus | |
calpastatin | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pulmonary microvascular endothelial cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | N-succinyl-LLVY + 7-amino-4-methylcoumarin | - |
? |
Organism | Comment | Expression |
---|---|---|
Mus musculus | in cultured pulmonary microvascular endothelial cells, incubation with septic plasma stimulates calpain activation. Reactive oxygen species produced from NADPH oxidase stimulates calpain-1 activation | up |
General Information | Comment | Organism |
---|---|---|
physiological function | calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditions | Mus musculus |