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Literature summary for 3.4.22.52 extracted from

  • Wang, Y.; Kim, N.S.; Li, X.; Greer, P.A.; Koehler, R.C.; Dawson, V.L.; Dawson, T.M.
    Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos) (2009), J. Neurochem., 110, 687-696.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
apoptosis-inducing factor + H2O Homo sapiens although calpain I cleaves recombinant apoptosis-inducing factor in a cell free system, in intact cells under conditions where endogenous calpain is activated by either N-methyl-D-aspartate or N-methyl-N'-nitro-N-nitrosoguanidine administration, apoptosis-inducing factor is not cleaved ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apoptosis-inducing factor + H2O although calpain I cleaves recombinant apoptosis-inducing factor in a cell free system, in intact cells under conditions where endogenous calpain is activated by either N-methyl-D-aspartate or N-methyl-N'-nitro-N-nitrosoguanidine administration, apoptosis-inducing factor is not cleaved Homo sapiens ?
-
 ?
E-(EDANS-)PLF-AERK-(Dabcyl) + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
calpain I
-
 Homo sapiens
mu-calpain
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function calpain I is not required for mitochondrial apoptosis-inducing factor release in poly(ADP-ribose) polymerase-1-dependent cell death Homo sapiens