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Literature summary for 3.4.22.52 extracted from

  • Averna, M.; Stifanese, R.; De Tullio, R.; Beccaria, F.; Salamino, F.; Pontremoli, S.; Melloni, E.
    Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells (2009), J. Neurochem., 110, 412-421.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
calpain inhibitor 1 synthetic calpain inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
neuronal nitric oxide synthase + H2O Homo sapiens the mechanism of neuronal nitric oxide synthase activation is promoted by a calpain-mediated limited proteolysis through conversion of native 160 kDa nNOS into a fully active 130 kDa ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
neuronal nitric oxide synthase + H2O the mechanism of neuronal nitric oxide synthase activation is promoted by a calpain-mediated limited proteolysis through conversion of native 160 kDa nNOS into a fully active 130 kDa Homo sapiens ?
-
?
tert-butyloxycarbonyl-Leu-Met-7-amido-4-chloromethylcoumarin + H2O
-
Homo sapiens tert-butyloxycarbonyl-Leu-Met + 7-amino-4-chloromethylcoumarin
-
?

Synonyms

Synonyms Comment Organism
mu-calpain
-
Homo sapiens

General Information

General Information Comment Organism
physiological function mu-calpain is specifically recruited into the NMDA receptor-neuronal nitric oxide synthase-heat shock protein 90 complex following calcium loading Homo sapiens