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Literature summary for 3.4.22.52 extracted from
- Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreading (2002), J. Biol. Chem., 277, 24435-24441.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RhoA + H2O | Bos taurus | calpain cleaves RhoA and generates a form that inhibits integrin-induced stress fiber assembly and cell spreading | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | from aorta | Bos taurus | - |
| skeletal muscle | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| RhoA + H2O | - |
Bos taurus | ? | - |
? | |
| RhoA + H2O | calpain cleaves RhoA and generates a form that inhibits integrin-induced stress fiber assembly and cell spreading | Bos taurus | ? | - |
? | |
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Release 2023.1 (January 2023)
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