Literature summary for 3.4.22.49 extracted from

Matsuo, K.; Ohsumi, K.; Iwabuchi, M.; Kawamata, T.; Ono, Y.; Takahashi, M.
Kendrin is a novel substrate for separase involved in the licensing of centriole duplication (2012), Curr. Biol., 22, 915-921.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
centrosome	-	Homo sapiens	5813	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
kendrin + H2O	Homo sapiens	kendrin, also named pericentrin and specifically cleaved at a consensus site (R2231), is a crucial substrate for separase at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q14674	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
kendrin + H2O	kendrin, also named pericentrin and specifically cleaved at a consensus site (R2231), is a crucial substrate for separase at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)