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Literature summary for 3.4.22.49 extracted from

  • Bessat, M.; Ersfeld, K.
    Functional characterization of cohesin SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei (2009), Mol. Microbiol., 71, 1371-1385.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
continuous overexpression of cmyc tagged TbSep is lethal to the cells Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm prodominant localisation Trypanosoma brucei 5737
-
additional information Separase is present in the cell during the entire cell cycle, but excluded from the nucleus until the metaphase-anaphase transition Trypanosoma brucei
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
126000
-
calculated mass of the native separase, SDS-PAGE, Western blot Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei TbSep is essential for the segregation of both large and minichromosomes (RNAi experiment) ?
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TbSep is essential for the segregation of both large and minichromosomes (RNAi experiment) Trypanosoma brucei ?
-
?

Synonyms

Synonyms Comment Organism
separase
-
Trypanosoma brucei
TbSep
-
Trypanosoma brucei