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Literature summary for 3.4.22.49 extracted from
- Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase (2009), Genes Dev., 23, 766-780.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cdc55 | results suggest that Cdc55 acts as inhibitor downstream from shugoshin | Anaplasma marginale | |
| securin | destruction of securin occurs only upon the correct attachment of chromosomes to the spindle | Anaplasma marginale |  |
| shugoshin | prevents separase activation independently of securin, protein phosphatase 2A coupled to regulatory subunit Cdc55 is essential for Shugoshin-mediated inhibition | Anaplasma marginale |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anaplasma marginale | - |
several strains | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| separase | - |
Anaplasma marginale |
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Release 2023.1 (January 2023)
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