Literature summary for 3.4.22.49 extracted from

Meyer, R.; Fofanov, V.; Panigrahi, A.; Merchant, F.; Zhang, N.; Pati, D.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers (2009), Clin. Cancer Res., 15, 2703-2710.

Search for more literature for 3.4.22.49

Cloned(Commentary)

Cloned (Comment)	Organism
investigation of the expression level of separase across a wide range of human tumors. Overexpression of separase transcripts strongly correlates with high incidence of relapse, metastasis and lower 5-year overall survival rate in breast and prostate cancer patients.	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	in nondividing cells in healthy tissue, immunofluorescence microscopy	Homo sapiens	5737	-
nucleus	tumor cells significantly more abundant, immunofluorescence microscopy	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	increased expression of separase	Homo sapiens	-
colorectal cancer cell line	separase expression is very high in both normal nonneoplastic and neoplastic colons	Homo sapiens	-
osteosarcoma cell	increased expression of separase	Homo sapiens	-
prostate cancer cell line	increased expression of separase	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
separase	-	Homo sapiens

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Release 2023.1 (January 2023)