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Literature summary for 3.4.22.49 extracted from

  • Sun, Y.; Kucej, M.; Fan, H.Y.; Yu, H.; Sun, Q.Y.; Zou, H.
    Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner (2009), Cell, 137, 123-132.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
chromosome
-
Homo sapiens 5694
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cohesin + H2O Homo sapiens cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner (in vitro). Autocleavage of separase is not stimulated by DNA. Cleavage of the chromosome-associated cohesins is sensitive to nuclease treatment. Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cohesin + H2O cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
separase
-
Homo sapiens