Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chromosome | - |
Homo sapiens | 5694 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | Homo sapiens | cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
all bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage | cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner (in vitro). Autocleavage of separase is not stimulated by DNA. Cleavage of the chromosome-associated cohesins is sensitive to nuclease treatment. | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | cohesin cleavage by human separase requires DNA in a sequence-nonspecific manner | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
separase | - |
Homo sapiens |