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Literature summary for 3.4.22.49 extracted from
- A non-proteolytic function of separase links the onset of anaphase to mitotic exit (2003), Nat. Cell Biol., 5, 249-254.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| securin | securin regulates both the proteolytic and non-proteolytic activities of separase | Saccharomyces cerevisiae |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cohesin + H2O | Saccharomyces cerevisiae | separase triggers anaphase by cohesin cleavage, and triggers the release and activation of the phosphatase Cdc14 independently of its protease activity | cleaved cohesin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cohesin + H2O | separase triggers anaphase by cohesin cleavage, and triggers the release and activation of the phosphatase Cdc14 independently of its protease activity | Saccharomyces cerevisiae | cleaved cohesin | - |
? | |
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Release 2023.1 (January 2023)
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