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Literature summary for 3.4.22.49 extracted from
- The dual mechanism of separase regulation by securin (2002), Curr. Biol., 12, 973-982.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| securin | securin is required to support separase activity in anaphase | Saccharomyces cerevisiae |  |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H1531A | active site point mutation prevents Scc1 from being cleaved after binding | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| securin | inhibits the proteolytic activity of separase | Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | while inhibiting separase, securin is able to promote nuclear accumulation of separase | Saccharomyces cerevisiae | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
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Release 2023.1 (January 2023)
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