Activating Compound | Comment | Organism | Structure |
---|---|---|---|
securin | - |
Drosophila melanogaster | |
securin | activation may be due to separase localization | Saccharomyces cerevisiae | |
securin | activation may be due to separase localization | Schizosaccharomyces pombe |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
securin | - |
Drosophila melanogaster | |
securin | small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments | Homo sapiens | |
securin | small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments | Saccharomyces cerevisiae | |
securin | small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments | Schizosaccharomyces pombe |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif | Homo sapiens | |
Ca2+ | Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif | Saccharomyces cerevisiae | |
Ca2+ | Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif | Schizosaccharomyces pombe |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Scc1 + H2O | Homo sapiens | - |
cleaved Scc1 | - |
? | |
Scc1 + H2O | Schizosaccharomyces pombe | - |
cleaved Scc1 | - |
? | |
Scc1 + H2O | Saccharomyces cerevisiae | cleavage at 2 defined sites results in rapid destabilization of Scc1 and its dissociation from chromosomes | cleaved Scc1 | - |
? | |
Slk19 + H2O | Saccharomyces cerevisiae | - |
cleaved Slk19 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Schizosaccharomyces pombe | - |
- |
- |
Xenopus laevis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Scc1 + H2O | - |
Homo sapiens | cleaved Scc1 | - |
? | |
Scc1 + H2O | - |
Schizosaccharomyces pombe | cleaved Scc1 | - |
? | |
Scc1 + H2O | cleavage at 2 defined sites results in rapid destabilization of Scc1 and its dissociation from chromosomes | Saccharomyces cerevisiae | cleaved Scc1 | - |
? | |
Slk19 + H2O | - |
Saccharomyces cerevisiae | cleaved Slk19 | - |
? |