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Literature summary for 3.4.22.49 extracted from

  • Ross, K.E.; Cohen-Fix, O.
    Separase: a conserved protease separating more than just sisters (2002), Trends Cell Biol., 12, 1-3.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
securin
-
Drosophila melanogaster
securin activation may be due to separase localization Saccharomyces cerevisiae
securin activation may be due to separase localization Schizosaccharomyces pombe

Inhibitors

Inhibitors Comment Organism Structure
securin
-
Drosophila melanogaster
securin small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments Homo sapiens
securin small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments Saccharomyces cerevisiae
securin small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments Schizosaccharomyces pombe

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif Homo sapiens
Ca2+ Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif Saccharomyces cerevisiae
Ca2+ Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Scc1 + H2O Homo sapiens
-
cleaved Scc1
-
?
Scc1 + H2O Schizosaccharomyces pombe
-
cleaved Scc1
-
?
Scc1 + H2O Saccharomyces cerevisiae cleavage at 2 defined sites results in rapid destabilization of Scc1 and its dissociation from chromosomes cleaved Scc1
-
?
Slk19 + H2O Saccharomyces cerevisiae
-
cleaved Slk19
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-
Schizosaccharomyces pombe
-
-
-
Xenopus laevis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Scc1 + H2O
-
Homo sapiens cleaved Scc1
-
?
Scc1 + H2O
-
Schizosaccharomyces pombe cleaved Scc1
-
?
Scc1 + H2O cleavage at 2 defined sites results in rapid destabilization of Scc1 and its dissociation from chromosomes Saccharomyces cerevisiae cleaved Scc1
-
?
Slk19 + H2O
-
Saccharomyces cerevisiae cleaved Slk19
-
?