Literature summary for 3.4.22.46 extracted from

Dhiman, H.; Dhanjal, J.K.; Sharma, S.; Chacko, S.; Grover, S.; Grover, A.
Resisting resistant Mycobacterium tuberculosis naturally: mechanistic insights into the inhibition of the parasites sole signal peptidase Leader peptidase B (2013), Biochem. Biophys. Res. Commun., 433, 552-557.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2S,3R,4R)-2-{[2-(2,3-dihydroxyphenyl)-5,8-dihydroxy-4-oxo-4H-chromen-7-yl]oxy}-4-hydroxy-4-(hydroxymethyl)tetrahydrofuran-3-yl alpha-D-galactopyranoside	-	Mycobacterium tuberculosis
2-(3,4-dihydroxyphenyl)ethyl 4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-6-O-alpha-L-lyxopyranosyl-beta-D-glucopyranoside	-	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WKA1	-	-
Mycobacterium tuberculosis H37Rv	P9WKA1	-	-

Synonyms

Synonyms	Comment	Organism
leader peptidase B	-	Mycobacterium tuberculosis
LepB	-	Mycobacterium tuberculosis

General Information

General Information	Comment	Organism
malfunction	the inhibition of LepB results in repressing the cleavage of the signal peptide from the preproteins which would lead to arresting the folding of proteins which are essential for the growth and pathogenesis of Mycobacterium tuberculosis into their active mature conformation	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)