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Literature summary for 3.4.22.46 extracted from

  • Foeger, N.; Kuehnel, E.; Cencic, R.; Skern, T.
    The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions (2005), FEBS J., 272, 2602-2611.
    View publication on PubMed
Search for more literature for 3.4.22.46

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged enzyme in Escherichia coli strain JM101 Foot-and-mouth disease virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eukaryotic initiation factor eIF4GI + H2O Foot-and-mouth disease virus eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site ?
-
 ?
eukaryotic initiation factor eIF4GI + H2O Foot-and-mouth disease virus FMDV eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site ?
-
 ?
eukaryotic initiation factor eIF4GII + H2O Foot-and-mouth disease virus eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site ?
-
 ?
eukaryotic initiation factor eIF4GII + H2O Foot-and-mouth disease virus FMDV eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site ?
-
 ?

Organism

Organism UniProt Comment Textmining
Foot-and-mouth disease virus
-
 FMDV
-
Foot-and-mouth disease virus FMDV
-
 FMDV
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GST-tagged enzyme from Escherichia coli strain JM101 by glutathione affinity chromatography Foot-and-mouth disease virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eukaryotic initiation factor eIF4GI + H2O eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site Foot-and-mouth disease virus ?
-
 ?
eukaryotic initiation factor eIF4GI + H2O eukaryotic host cell protein substrate, cleavage between residues G674 and R675, the enzyme binds to substrate residues 640-669 and interacts with C133 and residues 183-195, interaction analysis of enzyme with recombinant peptide fragments, reduced binding with mutated peptides K643A, K646A, and R650A overview Foot-and-mouth disease virus ?
-
 ?
eukaryotic initiation factor eIF4GI + H2O eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site Foot-and-mouth disease virus FMDV ?
-
 ?
eukaryotic initiation factor eIF4GI + H2O eukaryotic host cell protein substrate, cleavage between residues G674 and R675, the enzyme binds to substrate residues 640-669 and interacts with C133 and residues 183-195, interaction analysis of enzyme with recombinant peptide fragments, reduced binding with mutated peptides K643A, K646A, and R650A overview Foot-and-mouth disease virus FMDV ?
-
 ?
eukaryotic initiation factor eIF4GII + H2O eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site Foot-and-mouth disease virus ?
-
 ?
eukaryotic initiation factor eIF4GII + H2O eukaryotic host cell protein substrate Foot-and-mouth disease virus ?
-
 ?
eukaryotic initiation factor eIF4GII + H2O eukaryotic host cell protein substrate, cleavage prevents the synthesis of host cellular protein from capped cellular mRNAs, while the viral RNA is tsill translated initiating from an internal ribosome entry site Foot-and-mouth disease virus FMDV ?
-
 ?
eukaryotic initiation factor eIF4GII + H2O eukaryotic host cell protein substrate Foot-and-mouth disease virus FMDV ?
-
 ?
additional information substrate recognition and cleavage site specificity, overview Foot-and-mouth disease virus ?
-
 ?
additional information substrate recognition and cleavage site specificity, overview Foot-and-mouth disease virus FMDV ?
-
 ?

Synonyms

Synonyms Comment Organism
Leader proteinase
-
 Foot-and-mouth disease virus
Lpro
-
 Foot-and-mouth disease virus