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Literature summary for 3.4.22.46 extracted from

  • Piccone, M.E.; Zellner, M.; Kumosinski, T.F.; Mason, P.W.; Grubman, M.J.
    Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus (1995), J. Virol., 69, 4950-4956.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.46

Cloned(Commentary)

Cloned (Comment) Organism
-
 Foot-and-mouth disease virus

Protein Variants

Protein Variants Comment Organism
C23A no activity Foot-and-mouth disease virus
C23S no activity Foot-and-mouth disease virus
D136N reduced activity Foot-and-mouth disease virus
E48Q active mutant Foot-and-mouth disease virus
H110L active mutant, nearly as active as wild-type Foot-and-mouth disease virus
H120L no activity Foot-and-mouth disease virus
H81L active mutant Foot-and-mouth disease virus

Inhibitors

Inhibitors Comment Organism Structure
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E-64 Foot-and-mouth disease virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
foot-and-mouth disease leader protein + H2O Foot-and-mouth disease virus cis and trans cleavage activity at the L/P1 junction ?
-
 ?
translation initiation factor eIF4G + H2O Foot-and-mouth disease virus i.e. p220 additional information
-
 ?

Organism

Organism UniProt Comment Textmining
Foot-and-mouth disease virus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
foot-and-mouth disease leader protein + H2O cis and trans cleavage activity at the L/P1 junction Foot-and-mouth disease virus ?
-
 ?
translation initiation factor eIF4G + H2O i.e. p220 Foot-and-mouth disease virus additional information
-
 ?