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Literature summary for 3.4.22.40 extracted from

  • Ratovitski, T.; Chighladze, E.; Waldron, E.; Hirschhorn, R.R.; Ross, C.A.
    Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin (2011), J. Biol. Chem., 286, 12578-12589.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in HT-22 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
endosome
-
 Homo sapiens 5768
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
huntingtin + H2O Homo sapiens the enzyme is involved in a specific cleavage step at the N-terminal fragment cp-2 site of huntingtin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
huntingtin + H2O the enzyme is involved in a specific cleavage step at the N-terminal fragment cp-2 site of huntingtin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Blmh
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of bleomycin hydrolase reduces cp-2 cleavage, and ameliorates mutant huntingtin induced toxicity Homo sapiens