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Literature summary for 3.4.22.40 extracted from
- Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase (2012), Amino Acids, 43, 1339-1348.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-homocysteine-thiolactone + H2O | Mus musculus | - |
L-homocysteine | - |
? |  |
| additional information | Mus musculus | bleomycin hydrolase does not hydrolyze D-Hcy-thiolactone | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-homocysteine-thiolactone + H2O | - |
Mus musculus | L-homocysteine | - |
? | |
| additional information | bleomycin hydrolase does not hydrolyze D-Hcy-thiolactone | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Blmh | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | bleomycin hydrolase knockout mice excrete up to 10fold more L-homocysteine-thiolactone than normal animals | Mus musculus |
| physiological function | bleomycin hydrolase protects against L-homocysteine-thiolactone toxicity in brain and kidney | Mus musculus |
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Release 2023.1 (January 2023)
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