Literature summary for 3.4.22.38 extracted from

Hussein, H.; Boyaka, P.; Dulin, J.; Russell, D.; Smanik, L.; Azab, M.; Bertone, A.L.
Cathepsin K localizes to equine bone in vivo and inhibits bone marrow atem and progenitor cells differentiation in vitro (2017), J. Stem Cells Regen. Med., 13, 45-53 .

Search for more literature for 3.4.22.38

Application

Application	Comment	Organism
medicine	selective inhibition of cathepsin K has a therapeutic potential for diseases associated with bone loss and osseous inflammation, such as osteoarthritis, periodontitis, and osteoporosis. Cathepsin K inhibition may have anabolic effects on bone and cartilage regeneration that may be explained as a feedback response to cathepsin K depletion. The use of cathepsin K inhibition to reduce inflammation and associated bone resorption in equine osseous disorders may offer advantages to other therapeutics	Equus caballus

Inhibitors

Inhibitors	Comment	Organism	Structure
VEL-0230	highly selective inhibitor of CatK that significantly decreases bone resorption and increases bone formation biomarkers	Equus caballus

Organism

Organism	UniProt	Comment	Textmining
Equus caballus	F7A8R5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
osteoclast	-	Equus caballus	-

Synonyms

Synonyms	Comment	Organism
catK	-	Equus caballus

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Release 2023.1 (January 2023)