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Literature summary for 3.4.22.38 extracted from

  • Bitu, C.C.; Kauppila, J.H.; Bufalino, A.; Nurmenniemi, S.; Teppo, S.; Keinaenen, M.; Vilen, S.T.; Lehenkari, P.; Nyberg, P.; Coletta, R.D.; Salo, T.
    Cathepsin K is present in invasive oral tongue squamous cell carcinoma in vivo and in vitro (2013), PLoS ONE, 8, e70925.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.38

Inhibitors

Inhibitors Comment Organism Structure
E-64
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen type I + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HSC-3 cell
-
 Homo sapiens
-
oral tongue squamous cell carcinoma cell
-
 Homo sapiens
-
stromal cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen type I + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Cat-K
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction specific cathepsin K knockdown significantly reduces HSC-3 cell invasion in the myoma organotypic invasion model Homo sapiens
physiological function cathepsin K in the invasive tumor microenvironment front has a protective role in the complex progression of tongue cancer Homo sapiens