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Literature summary for 3.4.22.38 extracted from

  • Hu, L.; Cheng, X.W.; Song, H.; Inoue, A.; Jiang, H.; Li, X.; Shi, G.P.; Kozawa, E.; Okumura, K.; Kuzuya, M.
    Cathepsin K activity controls injury-related vascular repair in mice (2014), Hypertension, 63, 607-615.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.38

Inhibitors

Inhibitors Comment Organism Structure
CatK-II specific inhibitor Mus musculus
E-64 i.e. epoxysuccinyl-L-leucylamido-{4-guanidino} butane, nonspecific inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen type I + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen type I + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
catK
-
 Mus musculus

General Information

General Information Comment Organism
malfunction ablation of cathepsin K mitigates injury-induced neointimal hyperplasia. Smooth muscle cell movement is impaired in enzyme-deficient mice. Enzyme inhibition alleviates vascular remodeling. Enzyme deficiency also impairs the smooth muscle cell proliferation ability induced by platelet-derived growth factor-BB. Enzyme deficiency impairs inflammatory action in response to injury Mus musculus