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Literature summary for 3.4.22.38 extracted from

  • Codriansky, K.A.; Quintanilla-Dieck, M.J.; Gan, S.; Keady, M.; Bhawan, J.; Ruenger, T.M.
    Intracellular degradation of elastin by cathepsin K in skin fibroblasts--a possible role in photoaging (2009), Photochem. Photobiol., 85, 1356-1363.
    View publication on PubMed
Search for more literature for 3.4.22.38

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast
-
 Homo sapiens
-
synovial fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
catK
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens induction of cathepsin K expression in fibroblasts from young donors but not from old donors is observed both in vitro and in vivo after exposure to longwave UV-A (100-500 kJ/m2) in a time-dependent manner with a maximum 2 days after exposure. Induction of active cathepsin K is also seen 1 day after irradiation with UV-B and less so after exposure to ionizing radiation followed by decreased levels on the following days up

General Information

General Information Comment Organism
physiological function cathepsin K-mediated intracellular elastin degradation may play a role in the formation of solar elastosis Homo sapiens