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Literature summary for 3.4.22.38 extracted from

  • Lendeckel, U.; Kaehne, T.; Ten Have, S.; Bukowska, A.; Wolke, C.; Bogerts, B.; Keilhoff, G.; Bernstein, H.G.
    Cathepsin K generates enkephalin from beta-endorphin: a new mechanism with possible relevance for schizophrenia (2009), Neurochem. Int., 54, 410-417.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-endorphin + H2O Homo sapiens
-
 Met-enkephalin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
infundibular nucleus increased numbers of cathepsin K immunoreactive cells are found in left and right arcuate nucleus of schizophrenics Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-endorphin + H2O
-
 Homo sapiens Met-enkephalin + ?
-
 ?

Expression

Organism Comment Expression
Homo sapiens cathepsin K becomes up-regulated in its cerebral expression by neuroleptic treatment up

General Information

General Information Comment Organism
physiological function cathepsin K may significantly contribute to altered opioid levels in brains of schizophrenics Homo sapiens