Literature summary for 3.4.22.38 extracted from

Rankovic, Z.; Cai, J.; Kerr, J.; Fradera, X.; Robinson, J.; Mistry, A.; Hamilton, E.; McGarry, G.; Andrews, F.; Caulfield, W.; Cumming, I.; Dempster, M.; Waller, J.; Scullion, P.; Martin, I.; Mitchell, A.; Long, C.; Baugh, M.; Westwood, P.; Kinghorn, E.; Bruin, J.; Hamilton, W.; Uitdehaag, J.; van Z, v.a.n..Z.e.
Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 1524-1527.

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Inhibitors

Inhibitors	Comment	Organism
4-(3,4-dimethylphenyl)-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-(3-cyanophenyl)-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-(3-cyclopentylphenyl)-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-(3-methylphenyl)-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-(3-tert-butylphenyl)-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-cycloheptyl-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-cycloheptyl-6-[3-(piperidin-1-yl)propyl]pyrimidine-2-carbonitrile	-	Homo sapiens
4-cyclohexyl-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-cyclooctyl-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-phenyl-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-propyl-6-[2-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile	-	Homo sapiens
4-propyl-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile	moderate cathepsin K potency	Homo sapiens
4-propyl-6-[4-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile	-	Homo sapiens
4-[2-chloro-3-(trifluoromethyl)phenyl]-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-[3-(methylsulfonyl)phenyl]-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens
4-[3-(pentan-3-ylamino)propyl]-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile	-	Homo sapiens
4-[3-(piperidin-1-yl)propyl]-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile	-	Homo sapiens
4-[3-(tert-butylamino)propyl]-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile	-	Homo sapiens
4-[4-chloro-3-(trifluoromethyl)phenyl]-6-propylpyrimidine-2-carbonitrile	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
catK	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000004	-	pH and temperature not specified in the publication	Homo sapiens	4-[3-(piperidin-1-yl)propyl]-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile
0.000004	-	pH and temperature not specified in the publication	Homo sapiens	4-[3-(pentan-3-ylamino)propyl]-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile
0.00001	-	pH and temperature not specified in the publication	Homo sapiens	4-[3-(tert-butylamino)propyl]-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile
0.000011	-	pH and temperature not specified in the publication	Homo sapiens	4-(3-tert-butylphenyl)-6-propylpyrimidine-2-carbonitrile
0.000011	-	pH and temperature not specified in the publication	Homo sapiens	4-cyclooctyl-6-propylpyrimidine-2-carbonitrile
0.000033	-	pH and temperature not specified in the publication	Homo sapiens	4-propyl-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile
0.000034	-	pH and temperature not specified in the publication	Homo sapiens	4-[4-chloro-3-(trifluoromethyl)phenyl]-6-propylpyrimidine-2-carbonitrile
0.000084	-	pH and temperature not specified in the publication	Homo sapiens	4-cycloheptyl-6-propylpyrimidine-2-carbonitrile
0.000096	-	pH and temperature not specified in the publication	Homo sapiens	4-(3,4-dimethylphenyl)-6-propylpyrimidine-2-carbonitrile
0.0001	-	pH and temperature not specified in the publication	Homo sapiens	4-cycloheptyl-6-[3-(piperidin-1-yl)propyl]pyrimidine-2-carbonitrile
0.000148	-	pH and temperature not specified in the publication	Homo sapiens	4-[3-(methylsulfonyl)phenyl]-6-propylpyrimidine-2-carbonitrile
0.000181	-	pH and temperature not specified in the publication	Homo sapiens	4-(3-methylphenyl)-6-propylpyrimidine-2-carbonitrile
0.000293	-	pH and temperature not specified in the publication	Homo sapiens	4-(3-cyanophenyl)-6-propylpyrimidine-2-carbonitrile
0.000457	-	pH and temperature not specified in the publication	Homo sapiens	4-(3-cyclopentylphenyl)-6-propylpyrimidine-2-carbonitrile
0.00068	-	pH and temperature not specified in the publication	Homo sapiens	4-cyclohexyl-6-propylpyrimidine-2-carbonitrile
0.000985	-	pH and temperature not specified in the publication	Homo sapiens	4-phenyl-6-propylpyrimidine-2-carbonitrile
0.001	-	pH and temperature not specified in the publication	Homo sapiens	4-propyl-6-[4-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile
0.001	-	pH and temperature not specified in the publication	Homo sapiens	4-[2-chloro-3-(trifluoromethyl)phenyl]-6-propylpyrimidine-2-carbonitrile
0.004074	-	pH and temperature not specified in the publication	Homo sapiens	4-propyl-6-[2-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile