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Literature summary for 3.4.22.38 extracted from

  • Mikosch, P.; Kerschan-Schindl, K.; Woloszczuk, W.; Stettner, H.; Kudlacek, S.; Kresnik, E.; Gallowitsch, H.J.; Lind, P.; Pietschmann, P.
    High cathepsin K levels in men with differentiated thyroid cancer on suppressive L-thyroxine therapy (2008), Thyroid, 18, 27-33.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information cathepsin K is increased by a suppressive L-thyroxine therapy Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular cathepsin K is secreted by osteoclasts, when they are resorbing bone Homo sapiens
-
-
lysosome
-
Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin K plays a role in osteoclast mediated bone resorption, it is responsible for the degradation of the collagen matrix of the bone after the removal of its mineral components. Deficiency of cathepsin K causes pycnodysostosis, a rare skeletal dysplasia presenting with bone abnormalities such as short stature, osteosclerosis, acro-osteolysis of distal phalanges, and skull deformities ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone cathepsin K is increased by a suppressive L-thyroxine therapy and decreases with increasing age, overview Homo sapiens
-
additional information high cathepsin K levels in men with differentiated thyroid cancer on suppressive L-thyroxine therapy, overview Homo sapiens
-
osteoclast cathepsin K is secreted by osteoclasts, when they are resorbing bone Homo sapiens
-
serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin K plays a role in osteoclast mediated bone resorption, it is responsible for the degradation of the collagen matrix of the bone after the removal of its mineral components. Deficiency of cathepsin K causes pycnodysostosis, a rare skeletal dysplasia presenting with bone abnormalities such as short stature, osteosclerosis, acro-osteolysis of distal phalanges, and skull deformities Homo sapiens ?
-
?