Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is induced by bleomycin in the lung | Mus musculus |
Application | Comment | Organism |
---|---|---|
drug development | lysosomal cysteine protease is an interesting target molecule with therapeutic potential to attenuate bleomycin-induced pulmonary fibrosis in mice | Mus musculus |
Cloned (Comment) | Organism |
---|---|
quantitative expression analysis by RT-PCR | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis, overview. Cathepsin K protein levels are strongly increased in alveolar macrophages and lung parenchymal tissue of mock-treated cathepsin K transgenic mice relative to wild-type mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
FVB/N mice | - |
Mus musculus FVB/N | - |
FVB/N mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | primary type II alveolar epithelial cells | Mus musculus | - |
fibroblast | - |
Mus musculus | - |
lung | qunatitative determination of enzyme content by immunohistochemistry, real time RT-PCR and western blotting | Mus musculus | - |
macrophage | alveolar | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cath K | - |
Mus musculus |