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Literature summary for 3.4.22.38 extracted from

  • Park, Y.; Kong, J.Y.; Cho, H.
    A furanquinone from Paulownia tomentosa stem for a new cathepsin K inhibitor (2009), Phytother. Res., 23, 1485-1488.
    View publication on PubMed
Search for more literature for 3.4.22.38

Cloned(Commentary)

Cloned (Comment) Organism
expression in Spodoptera frugiperda Sf21 cells driven by a polyhedrin promotor Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
carbobenzyloxy-Phe-Phe-CH2F
-
 Homo sapiens
methyl 5-acetoxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate
-
 Homo sapiens
methyl 5-hydroxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate furanquinone from Paulownia tomentosa stem Homo sapiens
methyl 5-methoxy dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate
-
 Homo sapiens
methyl 5-propoxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbobenzyloxy-Gly-Pro-Arg-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens carbobenzyloxy-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
carbobenzyloxy-Phe-Arg-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens carbobenzyloxy-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00066 0.00071 pH 5.5, 22°C, recombinant enzyme, dependent on the substrate Homo sapiens carbobenzyloxy-Phe-Phe-CH2F
0.0215 0.028 pH 5.5, 22°C, recombinant enzyme, dependent on the substrate Homo sapiens methyl 5-hydroxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate
0.0335 0.037 pH 5.5, 22°C, recombinant enzyme, dependent on the substrate Homo sapiens methyl 5-acetoxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate
0.04 0.042 pH 5.5, 22°C, recombinant enzyme, dependent on the substrate Homo sapiens methyl 5-propoxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate
0.045 0.067 pH 5.5, 22°C, recombinant enzyme, dependent on the substrate Homo sapiens methyl 5-methoxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate