Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
E64 | a nonselective cysteine protease inhibitor, complete inhibition | Mus musculus | |
additional information | stem bark extracts of Ulmus davidiana, a deciduous tree from Korea and an antiinflammatory in traditional Korean medicine, prevents the osteoclast-mediated intracellular processing of Cat K, suggesting that it may disrupt the intracellular transport of pro Cat K. Ulmus davidiana dose-dependently inhibits in vitro bone resorption with a potency similar to that observed for inhibition of Cat K processing | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
x * 32000, about, proenzyme | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | Cat K plays a key role in matrix degradation during bone resorption | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | processing of the proenzyme for activation involving reentry and delivery of proenzyme into lysosome which is enhanced by mannose-6-phosphate and mediated by the mannose-6-phosphate receptor, overview | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Mus musculus | - |
long bone | - |
Mus musculus | - |
osteoblast | - |
Mus musculus | - |
osteoclast | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
osteoclast resorption activity | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbobenzyloxy-Leu-Arg-4-methoxy-2-naphthylamide + H2O | - |
Mus musculus | carbobenzyloxy-Leu-Arg + 4-methoxy-2-naphthylamine | - |
? | |
additional information | Cat K plays a key role in matrix degradation during bone resorption | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 32000, about, proenzyme | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
Cat K | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
Ulmus diviana stem bral extracts show an IC50 of 0.0875 mg/ml | Mus musculus | additional information |