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Literature summary for 3.4.22.38 extracted from

  • Guo, J.; Bot, I.; de Nooijer, R.; Hoffman, S.J.; Stroup, G.B.; Biessen, E.A.; Benson, G.M.; Groot, P.H.; Van Eck, M.; Van Berkel, T.J.
    Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice (2009), Cardiovasc. Res., 81, 278-285.
    View publication on PubMed
Search for more literature for 3.4.22.38

Application

Application Comment Organism
pharmacology CatK is an established drug target for osteoporosis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information bone marrow transplantation for selective disruption of CatK in the haematopoietic system, usage of total bone marrow progenitor cells from CatK-/-, CatK-/+, and CatK+/+, and low-density lipoprotein receptor knockout mice. Silencing of leucocyte CatK results in phenotypic changes in bone formation with an increased total bone mineral density in the CatK2/2 chimeras, effect of leucocyte cathepsin K deficiency on bone remodelling, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus absence of leucocyte CatK results in dramatically decreased collagen and increased macrophage content of the atherosclerotic lesions while lesion size is not affected ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
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leukocyte
-
 Mus musculus
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additional information CatK is upregulated in atherosclerotic lesions Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information absence of leucocyte CatK results in dramatically decreased collagen and increased macrophage content of the atherosclerotic lesions while lesion size is not affected Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
catK
-
 Mus musculus