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Literature summary for 3.4.22.38 extracted from
- Role of cathepsin K in the turnover of the dermal extracellular matrix during scar formation (2007), J. Invest. Dermatol., 127, 293-297.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | it is suggested that cathepsin K plays an important role in the homeostasis of the dermal extracellular matrix and the dynamic equilibrium between matrix synthesis and proteolytic degradation, by counteracting deposition of matrix proteins during scar formation with its matrix-degrading activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| dermatofibroma cell | strongly expressed | Homo sapiens | - |
| keloid | strongly expressed | Homo sapiens | - |
| additional information | cathepsin is also found to be strongly expressed in keloids and in dermatofibromas, but not in sclerotic areas of morphea | Homo sapiens | - |
| skin | normal skin shows only low levels or no expression of cathepsin K. Dermal fibroblasts in surgical scars shows strong cytoplasmatic expression of cathepsin K. Expresson is most prominent in young scars and declines with time | Homo sapiens | - |
| skin fibroblast | cultured neonatal primary fibroblasts show strong cathepsin K staining in the perinuclear endosomal compartment | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cathepsin K | - |
Homo sapiens |
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