Activating Compound | Comment | Organism | Structure |
---|---|---|---|
DTT | - |
Homo sapiens | |
DTT | - |
Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | it is shown that cathepsin K acts as a potent kinin-degrading enzyme in bloodstream. Contrary to cathepsin L, cathepsin K attenuates kallikrein-induced decrease of rat blood pressure, and reduces the hypotensive effect of bradykinin in a dose-dependant manner | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in Pichia pastoris | Homo sapiens |
expressed in Pichia pastoris | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
Y67L/L205A | this mutant fails to degrade bradykinin, indicating that Tyr67 and Leu205 are key active site residues for the kinin degrading activity of cathepsin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
plasma | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | - |
Homo sapiens | bradykinin(1-4) + bradykinin(5-9) | - |
? | |
bradykinin + H2O | - |
Rattus norvegicus | bradykinin(1-4) + bradykinin(5-9) | - |
? | |
desArg-bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
desArg-bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Lys-bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
Lys-bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
o-aminobenzoyl-bradykinin-(3-NO2-Tyr) + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin K | - |
Homo sapiens |
cathepsin K | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
28 | - |
assay at | Homo sapiens |
28 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
assay at | Homo sapiens |
5.5 | - |
assay at | Rattus norvegicus |