Crystallization (Comment) | Organism |
---|---|
crysallized from 20% MPD, 0.1 M Tris, pH 7 and 0.1 M MES, pH 6, crystals were flash frozen in a nitrogen stream after increasing the MPD concentration to aproximately 30% | Oryctolagus cuniculus |
hanging drop vapour diffusion method | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y61D/V157L | corresponding to the amino acid at that position in human enzyme, yields an enzyme with kinetic constants and inhibitor specificity profiles equivalent to human ortholog | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S,S)-piperidine-4-carboxylic acid [1-[1-(benzoxazole-2-carbonyl)-3-phenyl-propylcarbamoyl]-3-methyl-butyl]-amide | - |
Homo sapiens | |
(S,S)-piperidine-4-carboxylic acid [1-[1-(benzoxazole-2-carbonyl)-3-phenyl-propylcarbamoyl]-3-methyl-butyl]-amide | - |
Oryctolagus cuniculus | |
piperidine-4-carboxylic acid [3-methyl-1[1-(1-oxa-3-aza-cyclopenta[a]naphthalene-2-carbonyl)-3-phenyl-propylcarbamoyl]-butyl]-amide trifluoroacetate | - |
Homo sapiens | |
piperidine-4-carboxylic acid [3-methyl-1[1-(1-oxa-3-aza-cyclopenta[a]naphthalene-2-carbonyl)-3-phenyl-propylcarbamoyl]-butyl]-amide trifluoroacetate | - |
Oryctolagus cuniculus | |
piperidine-4-carboxylic acid [3-methyl-1[1-(naphtho[1,2-d]oxazole-2-carbonyl)-3-phenyl-propylcarbamoyl]-butyl]-amide trifluoroacetate | - |
Homo sapiens | |
piperidine-4-carboxylic acid [3-methyl-1[1-(naphtho[1,2-d]oxazole-2-carbonyl)-3-phenyl-propylcarbamoyl]-butyl]-amide trifluoroacetate | - |
Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.019 | - |
CBZ-Phe-Arg-4-methylcoumarin 7-amide | - |
Oryctolagus cuniculus | |
0.036 | - |
CBZ-Phe-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CBZ-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | CBZ-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
CBZ-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Oryctolagus cuniculus | CBZ-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000001 | - |
piperidine-4-carboxylic acid [3-methyl-1[1-(naphtho[1,2-d]oxazole-2-carbonyl)-3-phenyl-propylcarbamoyl]-butyl]-amide trifluoroacetate | 21-24°C, pH 5.5 | Homo sapiens | |
0.000002 | - |
piperidine-4-carboxylic acid [3-methyl-1[1-(naphtho[1,2-d]oxazole-2-carbonyl)-3-phenyl-propylcarbamoyl]-butyl]-amide trifluoroacetate | 21-24°C, pH 5.5 | Oryctolagus cuniculus |