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Literature summary for 3.4.22.38 extracted from

  • Billington, C.J.; Mason, P.; Magny, M.C.; Mort, J.S.
    The slow-binding inhibition of cathepsin K by its propeptide (2000), Biochem. Biophys. Res. Commun., 276, 924-929.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Pichia pastoris Homo sapiens
expression of the propeptide in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cathepsin K propeptide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-Phe-Arg-4-methylcoumarin 7-amide + H2O
-
Homo sapiens Z-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000026
-
cathepsin K propeptide 25°C, pH 6 Homo sapiens
0.000147
-
cathepsin K propeptide 25°C, pH 4 Homo sapiens