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Literature summary for 3.4.22.38 extracted from

  • Kafienah, W.; Brömme, D.; Buttle, D.J.; Croucher, L.J.; Hollander, A.P.
    Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix (1996), Biochem. J., 331, 727-732.
No PubMed abstract available
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Protein + H2O Homo sapiens remodeling of extracellular bone matrix, together with other collagenolytic and gelatinolytic enzymes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen type I + H2O
-
 Homo sapiens Fragemnts of collagen type I cleavage near the N-terminal region within the helical domain, Pro in P2- position ?
Collagen type II + H2O
-
 Homo sapiens Fragments of collagen type II cleavage near the N-terminal region within the helical domain, Pro in P2- position ?
Gelatin + H2O
-
 Homo sapiens Fragments of gelatin
-
 ?
Protein + H2O remodeling of extracellular bone matrix, together with other collagenolytic and gelatinolytic enzymes Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4 7 substrate gelatin Homo sapiens