Literature summary for 3.4.22.37 extracted from

Froehlich, E.; Kantyka, T.; Plaza, K.; Schmidt, K.H.; Pfister, W.; Potempa, J.; Eick, S.
Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis (2013), Mol. Oral Microbiol., 28, 192-203.

Search for more literature for 3.4.22.37

Inhibitors

Inhibitors	Comment	Organism	Structure
2,6-bis-(4-amidinobenzyl)-cyclohexanone	-	Porphyromonas gingivalis
benzamidine	-	Porphyromonas gingivalis
Pentamidine	-	Porphyromonas gingivalis

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
45000	-	x * 45000, isoform RgpB, SDS-PAGE	Porphyromonas gingivalis
98000	-	x * 98000, isoform HRgpA, SDS-PAGE	Porphyromonas gingivalis

Organism

Organism	UniProt	Comment	Textmining
Porphyromonas gingivalis	P28784	isoform HRgpA	-
Porphyromonas gingivalis	P95493	isoform RgpB	-
Porphyromonas gingivalis ATCC 33277	P28784	isoform HRgpA	-
Porphyromonas gingivalis W83	P95493	isoform RgpB	-

Purification (Commentary)

Purification (Comment)	Organism
benzamidine-Sepharose column chromatography and Sephadex G-25 gel filtration	Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O	-	Porphyromonas gingivalis	N-alpha-benzoyl-DL-arginine + 4-nitroaniline	-	?
N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O	-	Porphyromonas gingivalis W83	N-alpha-benzoyl-DL-arginine + 4-nitroaniline	-	?
N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O	-	Porphyromonas gingivalis ATCC 33277	N-alpha-benzoyl-DL-arginine + 4-nitroaniline	-	?

Subunits

Subunits	Comment	Organism
?	x * 45000, isoform RgpB, SDS-PAGE	Porphyromonas gingivalis
?	x * 98000, isoform HRgpA, SDS-PAGE	Porphyromonas gingivalis

Synonyms

Synonyms	Comment	Organism
Arg-gingipain	-	Porphyromonas gingivalis
HRgpA	isoform	Porphyromonas gingivalis
RgpB	isoform	Porphyromonas gingivalis

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0029	-	2,6-bis-(4-amidinobenzyl)-cyclohexanone	at pH 7.6 and 37°C	Porphyromonas gingivalis
0.107	-	Pentamidine	at pH 7.6 and 37°C	Porphyromonas gingivalis
0.536	-	benzamidine	at pH 7.6 and 37°C	Porphyromonas gingivalis

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Release 2023.1 (January 2023)