Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-Phe-Pro-Arg-chloromethyl ketone | Porphyromonas gingivalis treated with gingipain inhibitor do not induce buccal edema and gingivitis in BALB/c or C57BL/6 mice | Porphyromonas gingivalis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Arg-gingipain | - |
Porphyromonas gingivalis |
Arg-gingipain A | - |
Porphyromonas gingivalis |
RgpA | - |
Porphyromonas gingivalis |
RgpB | - |
Porphyromonas gingivalis |
General Information | Comment | Organism |
---|---|---|
malfunction | Porphyromonas gingivalis RgpA/B double mutant do not induce buccal edema and gingivitis in BALB/c or C57BL/6 mice | Porphyromonas gingivalis |
physiological function | Porphyromonas gingivalis W83 (wild type), but not gingipain-deficient mutant or wild-type bacteria pretreated with gingipain inhibitors, elicit buccal edema and gingivitis in BALB/c or C57BL/6 mice. Studies in Toll-like receptors 2-/-, bradykinin B2 receptor -/-, and neutrophil-depleted C57BL/6 mice reveal that Porphyromonas gingivalis induce edema through the sequential activation of Toll-like receptors 2/neutrophils, with the initial plasma leakage being amplified by gingipain-dependent release of vasoactive kinins from plasma-borne kininogens | Porphyromonas gingivalis |