Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.37 extracted from

  • Kantyka, T.; Latendorf, T.; Wiedow, O.; Bartels, J.; Glaeser, R.; Dubin, G.; Schroeder, J.M.; Potempa, J.; Meyer-Hoffert, U.
    Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage (2009), Biol. Chem., 390, 1313-1320.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
elafin + H2O Porphyromonas gingivalis all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) ?
-
 ?
elafin + H2O Porphyromonas gingivalis all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) with RgpB being far more efficient than other gingipains. RgpB efficiently inactivates the inhibitory activity of elafin at subnanomolar concentrations through proteolysis limited to the Arg22-Cys23 peptide bond within the surface loop harboring the inhibitor active site ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis P28784
-
-
Porphyromonas gingivalis P95493
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
elafin + H2O all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) Porphyromonas gingivalis ?
-
 ?
elafin + H2O all three gingipains have the ability to degrade elafin (endogenous inhibitor secreted by epithelial cells) with RgpB being far more efficient than other gingipains. RgpB efficiently inactivates the inhibitory activity of elafin at subnanomolar concentrations through proteolysis limited to the Arg22-Cys23 peptide bond within the surface loop harboring the inhibitor active site Porphyromonas gingivalis ?
-
 ?
MeoSuc-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Porphyromonas gingivalis ?
-
 ?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
HRgpA
-
 Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Porphyromonas gingivalis