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Literature summary for 3.4.22.37 extracted from

  • Boisvert, H.; Duncan, M.J.
    Clathrin-dependent entry of a gingipain adhesin peptide and Porphyromonas gingivalis into host cells (2008), Cell. Microbiol., 10, 2538-2552.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
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 Porphyromonas gingivalis 9986
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extracellular in extracellular vesicles and soluble in the culture supernatant Porphyromonas gingivalis
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additional information gingipain adhesin domains are involved in targeting their associated proteolytic activities to cell surface receptors, colocalization of the arg-gingipain, RgpA, adhesin domain with fibronectin and the alpha5beta1 integrin receptor for fibronectin Porphyromonas gingivalis
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis gingipains are involved in bacterial adherence to host cells, RgpA binds to adhesin via its adhesin binding domain. Peptide A44 derived from the adhesin domain of RgpA plays a role in binding of Porphyromonas gingivalis to HEP-2 epithelial cells via cell surface receptors, e.g. clathrin, nocodazole and paclitaxel, which disrupt microtubule formation, block the interaction, while genistein does not ?
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 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information gingipains are involved in bacterial adherence to host cells, RgpA binds to adhesin via its adhesin binding domain. Peptide A44 derived from the adhesin domain of RgpA plays a role in binding of Porphyromonas gingivalis to HEP-2 epithelial cells via cell surface receptors, e.g. clathrin, nocodazole and paclitaxel, which disrupt microtubule formation, block the interaction, while genistein does not Porphyromonas gingivalis ?
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 ?
additional information RgpA and RgpB cleave proteins after arginine residues Porphyromonas gingivalis ?
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 ?

Subunits

Subunits Comment Organism
More RgpA possesses an adhesin domain Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
Arg-gingipain A
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 Porphyromonas gingivalis
Arg-gingipains B
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 Porphyromonas gingivalis
RgpA
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 Porphyromonas gingivalis
RgpB
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 Porphyromonas gingivalis