Literature summary for 3.4.22.37 extracted from

Ally, N.; Whisstock, J.C.; Sieprawska-Lupa, M.; Potempa, J.; Le Bonniec, B.F.; Travis, J.; Pike, R.N.
Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes (2003), Biochemistry, 42, 11693-11700.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protein + H2O	Porphyromonas gingivalis	-	peptides	-	?

Organism

Organism	UniProt	Comment	Textmining
Porphyromonas gingivalis	-	isoforms HRgpA and RgpB, the first containing 4 amino acid changes compared to the latter, which are D281N, Y283S, P286S, and N331K that all map to the region surrounding the active site	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fibrinogen A alpha-chain + H2O	major cleavage site at position 22, all isoforms	Porphyromonas gingivalis	28 kDa fragment + ?	the 28 kDa fragment is the major product of isoform HRgpA	?
fibrinogen B beta-chain + H2O	high activity of isoform HRgpA, which performs cleavage at 2 positions: 42 and 44	Porphyromonas gingivalis	?	-	?
additional information	substrate specificity for the C-terminal position next to the cleavage site of the different enzyme forms, overview	Porphyromonas gingivalis	?	-	?
protein + H2O	-	Porphyromonas gingivalis	peptides	-	?

Subunits

Subunits	Comment	Organism
More	molecular modeling of the catalytic domain structure of HRgpA based on the RgpB structure, isoforms HRgpA and RgpB, the first containing 4 amino acid changes compared to the latter, which are D281N, Y283S, P286S, and N331K that all map to the region surrounding the active site	Porphyromonas gingivalis

Synonyms

Synonyms	Comment	Organism
Arginine-specific gingipain	-	Porphyromonas gingivalis
gingipain-R	-	Porphyromonas gingivalis
HRgpA	-	Porphyromonas gingivalis
RgpB	-	Porphyromonas gingivalis

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Release 2023.1 (January 2023)