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Literature summary for 3.4.22.36 extracted from

  • Stierle, D.B.; Stierle, A.A.; Girtsman, T.; McIntyre, K.; Nichols, J.
    Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum (2012), J. Nat. Prod., 75, 262-266.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy-4,5-dicarboxypentadecanoic acid
-
Homo sapiens
berkedrimane A
-
Homo sapiens
berkedrimane B
-
Homo sapiens
N-acetyl-YVAD-CHO
-
Homo sapiens
secospiculisporic acid
-
Homo sapiens
spiculisporic acid
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-18 + H2O Homo sapiens
-
interleukin-18 propeptide
-
?
pro-interleukin-1beta + H2O Homo sapiens
-
interleukin-1beta propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-18 + H2O
-
Homo sapiens interleukin-18 propeptide
-
?
pro-interleukin-1beta + H2O
-
Homo sapiens interleukin-1beta propeptide
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.09
-
at 37°C, pH not specified in the publication Homo sapiens berkedrimane B
0.1
-
at 37°C, pH not specified in the publication Homo sapiens berkedrimane A