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Literature summary for 3.4.22.36 extracted from

  • Sollberger, G.; Strittmatter, G.E.; Grossi, S.; Garstkiewicz, M.; Auf dem Keller, U.; French, L.E.; Beer, H.D.
    Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes (2015), J. Invest. Dermatol., 135, 1395-1404.
    View publication on PubMed
Search for more literature for 3.4.22.36

Inhibitors

Inhibitors Comment Organism Structure
Val-Ala-Asp
-
 Homo sapiens
YVAD
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bap31 protein + H2O Homo sapiens
-
 ?
-
 ?
pro-interleukin-18 + H2O Homo sapiens
-
 interleukin-18 propeptide
-
 ?
pro-interleukin-1beta + H2O Homo sapiens
-
 interleukin-1beta propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bap31 protein + H2O
-
 Homo sapiens ?
-
 ?
pro-interleukin-18 + H2O
-
 Homo sapiens interleukin-18 propeptide
-
 ?
pro-interleukin-1beta + H2O
-
 Homo sapiens interleukin-1beta propeptide
-
 ?

General Information

General Information Comment Organism
physiological function caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes and therefore plays a protective role of the protease in UVB-induced skin cancer development Homo sapiens