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Literature summary for 3.4.22.36 extracted from

  • Hitzler, I.; Sayi, A.; Kohler, E.; Engler, D.B.; Koch, K.N.; Hardt, W.D.; Mueller, A.
    Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1beta and IL-18 (2012), J. Immunol., 188, 3594-3602.
    View publication on PubMed
Search for more literature for 3.4.22.36

Inhibitors

Inhibitors Comment Organism Structure
carboxyfluorescein-YVAD-fluoromethylketone
-
 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
10000
-
 x * 10000, autocatalytically activated subunit of caspase-1, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-18 + H2O Mus musculus
-
 interleukin-18 propeptide
-
 ?
pro-interleukin-1beta + H2O Mus musculus
-
 interleukin-1beta propeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carboxyfluorescein-YVAD-fluoromethylketone + H2O
-
 Mus musculus ?
-
 ?
pro-interleukin-18 + H2O
-
 Mus musculus interleukin-18 propeptide
-
 ?
pro-interleukin-1beta + H2O
-
 Mus musculus interleukin-1beta propeptide
-
 ?

Subunits

Subunits Comment Organism
? x * 10000, autocatalytically activated subunit of caspase-1, SDS-PAGE Mus musculus

Expression

Organism Comment Expression
Mus musculus caspase-1 is activated as a consequence of Helicobacter infection up

General Information

General Information Comment Organism
physiological function the processing and release of the regulatory caspase-1 substrate interleukin-18 counteracts the proinflammatory activities of another caspase-1 substrate, interleukin-1beta, thereby balancing control of the Helicobacter infection with the prevention of excessive gastric immunopathology Mus musculus