Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-Val-Ala-Asp-fluoromethylketone | broad-range caspase inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
MyD88 adaptor-like + H2O | Homo sapiens | caspase-1 cleaves the TLR adaptor MyD88 adaptor-like at position D198 | ? | - |
? | |
pro-interleukin-1beta + H2O | Homo sapiens | - |
mature interleukin-1beta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
HiTrap FF column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
MyD88 adaptor-like + H2O | caspase-1 cleaves the TLR adaptor MyD88 adaptor-like at position D198 | Homo sapiens | ? | - |
? | |
pro-interleukin-1beta + H2O | - |
Homo sapiens | mature interleukin-1beta + ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase-1-mediated MyD88 adaptor-like cleavage is not required for MyD88 adaptor-like interaction with Toll-like receptor 4 or MyD88, nor for MyD88 adaptor-like induced NF-kappaB activation | Homo sapiens |