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Literature summary for 3.4.22.36 extracted from

  • Okamoto, M.; Liu, W.; Luo, Y.; Tanaka, A.; Cai, X.; Norris, D.A.; Dinarello, C.A.; Fujita, M.
    Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta (2010), J. Biol. Chem., 285, 6477-6488.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
Z-WEHD-fluoromethylketone
-
 Homo sapiens
Z-YVAD-fluoromethylketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens
-
 mature interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
1205-Lu cell
-
 Homo sapiens
-
HS-294T cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
 Homo sapiens mature interleukin-1beta + ?
-
 ?

General Information

General Information Comment Organism
physiological function NACHT, LRR, and pyrin domain-containing protein 3 inflammasome is constitutively assembled and activated with cleavage of caspase-1 in human melanoma cells Homo sapiens