Literature summary for 3.4.22.36 extracted from

Joosten, L.A.; Netea, M.G.; Fantuzzi, G.; Koenders, M.I.; Helsen, M.M.; Sparrer, H.; Pham, C.T.; van der Meer, J.W.; Dinarello, C.A.; van den Berg, W.B.
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta (2009), Arthritis Rheum., 60, 3651-3662.

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Inhibitors

Inhibitors	Comment	Organism	Structure
pralnacasan	potent caspase 1 inhibitor	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pro-interleukin-1beta + H2O	-	Mus musculus	mature interleukin-1beta + ?	-	?

Expression

Organism	Comment	Expression
Mus musculus	caspase 1 activity is inhibited in mice lacking active cysteine proteases	down

General Information

General Information	Comment	Organism
malfunction	caspase 1 deficiency does not affect neutrophil-dominated joint inflammation, whereas in chronic arthritis, the lack of caspase 1 results in reduced joint inflammation and cartilage destruction	Mus musculus

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Release 2023.1 (January 2023)