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Literature summary for 3.4.22.36 extracted from

  • Kuijk, L.M.; Mandey, S.H.; Schellens, I.; Waterham, H.R.; Rijkers, G.T.; Coffer, P.J.; Frenkel, J.
    Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1 (2008), Mol. Immunol., 45, 2158-2165.
    View publication on PubMed
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-1 activation is stimulated by ATP and 120fold lipopolysaccharides Homo sapiens
simvastatin blocks inhibition of caspase-1 activation, simvastatin acts synergistically with lipopolysaccharides and causes an impairment of non-sterol isoprenoid biosynthesis, the isoprenyl intermediate GGPP could block activation of caspase-1 and interleukin-1beta release, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
geranylgeranyl diphosphate the isoprenyl intermediate of non-sterol isoprenoid biosynthesis blocks activation of caspase-1 Homo sapiens
pralnacasan a specific caspase-1 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens mevalonate kinase deficiency patients have overactive caspase-1, causing enhanced interleukin-1beta processing and subsequent inflammation in response to bacterial components ?
-
 ?
pro-interleukin-18 + H2O Homo sapiens
-
 interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O Homo sapiens caspase-1 activation leads to release of active interleukin-1beta from THP-1 cells, regulation, overview interleukin-1beta + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mononuclear cell high activity in from peripheral blood of mevalonate kinase deficiency patients Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information mevalonate kinase deficiency patients have overactive caspase-1, causing enhanced interleukin-1beta processing and subsequent inflammation in response to bacterial components Homo sapiens ?
-
 ?
pro-interleukin-18 + H2O
-
 Homo sapiens interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O
-
 Homo sapiens interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O caspase-1 activation leads to release of active interleukin-1beta from THP-1 cells, regulation, overview Homo sapiens interleukin-1beta + ?
-
 ?