Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | transcription of caspase-1 gene is increased upon lipopolysaccharide and interferon-gamma stimulation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
the caspase-1 gene maps on chromosome 11 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
cytoplasm | inactive pro-caspase-1 | Homo sapiens | 5737 | - |
extracellular | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 45000, inactive zymogen, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspase-1 is the prototype of the inflammatory caspases and is a component of the NALP3 inflammasome, a cytosolic multiprotein complex that mediates the processing of pro-inflammatory caspases and cytokines. The inflammasome represents the first line of defense against cellular stress and is a crucial component of innate immunity. Caspase-1 plays a central role in the mechanisms leading to labor particularly in the context of intrauterine infection/inflammation. Caspase-1 is increased in the amniotic fluid of women with preterm labor in the presence of intra-amniotic infection/inflammation | ? | - |
? | |
pro-interleukin-18 + H2O | Homo sapiens | - |
interleukin-18 + ? | - |
? | |
pro-interleukin-1beta + H2O | Homo sapiens | caspase-1 is the enzyme responsible for the cleavage and activation of interleukin-1beta, which is a potent pro-inflammatory cytokine | interleukin-1beta + ? | - |
? | |
pro-interleukin-33 + H2O | Homo sapiens | - |
interleukin-33 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amniotic fluid | increased enzyme content during pregnancy, women with spontaneous labor at term have a higher median caspase-1 amniotic fluid concentration than women at term without labor | Homo sapiens | - |
B-lymphocyte | - |
Homo sapiens | - |
Kupffer cell | - |
Homo sapiens | - |
microglia | - |
Homo sapiens | - |
monocyte | both the active and the precursor domains of caspase-1are localized in the cytoplasmatic matrix and on the cell surface | Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-1 is the prototype of the inflammatory caspases and is a component of the NALP3 inflammasome, a cytosolic multiprotein complex that mediates the processing of pro-inflammatory caspases and cytokines. The inflammasome represents the first line of defense against cellular stress and is a crucial component of innate immunity. Caspase-1 plays a central role in the mechanisms leading to labor particularly in the context of intrauterine infection/inflammation. Caspase-1 is increased in the amniotic fluid of women with preterm labor in the presence of intra-amniotic infection/inflammation | Homo sapiens | ? | - |
? | |
pro-interleukin-18 + H2O | - |
Homo sapiens | interleukin-18 + ? | - |
? | |
pro-interleukin-18 + H2O | interleukin-18 is synthesized as a 24 kDa inactive precursor lacking a signal peptide, which is cleaved after Asp35 by caspase-1 to yield an active 8 kDa molecule | Homo sapiens | interleukin-18 + ? | - |
? | |
pro-interleukin-1beta + H2O | caspase-1 is the enzyme responsible for the cleavage and activation of interleukin-1beta, which is a potent pro-inflammatory cytokine | Homo sapiens | interleukin-1beta + ? | - |
? | |
pro-interleukin-1beta + H2O | cleavage between Asp116 and Ala117, required for activation of the cytokine | Homo sapiens | interleukin-1beta + ? | - |
? | |
pro-interleukin-33 + H2O | - |
Homo sapiens | interleukin-33 + ? | - |
? | |
pro-interleukin-33 + H2O | activation | Homo sapiens | interleukin-33 + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 45000, inactive zymogen, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ICE | - |
Homo sapiens |
interleukin-1beta converting enzyme | - |
Homo sapiens |