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Literature summary for 3.4.22.36 extracted from

  • Rosenzweig, H.L.; Martin, T.M.; Planck, S.R.; Galster, K.; Jann, M.M.; Davey, M.P.; Kobayashi, K.; Flavell, R.A.; Rosenbaum, J.T.
    Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling (2008), J. Leukoc. Biol., 84, 529-536.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-18 + H2O Mus musculus caspase-1 is essential for interleukin-1beta and interleukin-18 production in the eye in response to muramyl dipeptide. Activation of NOD2 results in IL-1beta production via a caspase-1-dependent mechanism, interleukin-1beta and caspase-1 contribute to muramyl dipeptide-induced ocular inflammation, overview interleukin-18 + ?
-
?
pro-interleukin-18 + H2O Mus musculus BALB/c caspase-1 is essential for interleukin-1beta and interleukin-18 production in the eye in response to muramyl dipeptide. Activation of NOD2 results in IL-1beta production via a caspase-1-dependent mechanism, interleukin-1beta and caspase-1 contribute to muramyl dipeptide-induced ocular inflammation, overview interleukin-18 + ?
-
?
pro-interleukin-1beta + H2O Mus musculus caspase-1 is essential for interleukin-1beta and interleukin-18 production in the eye in response to muramyl dipeptide. Activation of NOD2 results in IL-1beta production via a caspase-1-dependent mechanism, interleukin-1beta and caspase-1 contribute to muramyl dipeptide-induced ocular inflammation, overview interleukin-1beta + ?
-
?
pro-interleukin-1beta + H2O Mus musculus BALB/c caspase-1 is essential for interleukin-1beta and interleukin-18 production in the eye in response to muramyl dipeptide. Activation of NOD2 results in IL-1beta production via a caspase-1-dependent mechanism, interleukin-1beta and caspase-1 contribute to muramyl dipeptide-induced ocular inflammation, overview interleukin-1beta + ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
Balb/c mice
-
Mus musculus BALB/c
-
Balb/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-18 + H2O
-
Mus musculus interleukin-18 + ?
-
?
pro-interleukin-18 + H2O caspase-1 is essential for interleukin-1beta and interleukin-18 production in the eye in response to muramyl dipeptide. Activation of NOD2 results in IL-1beta production via a caspase-1-dependent mechanism, interleukin-1beta and caspase-1 contribute to muramyl dipeptide-induced ocular inflammation, overview Mus musculus interleukin-18 + ?
-
?
pro-interleukin-18 + H2O
-
Mus musculus BALB/c interleukin-18 + ?
-
?
pro-interleukin-18 + H2O caspase-1 is essential for interleukin-1beta and interleukin-18 production in the eye in response to muramyl dipeptide. Activation of NOD2 results in IL-1beta production via a caspase-1-dependent mechanism, interleukin-1beta and caspase-1 contribute to muramyl dipeptide-induced ocular inflammation, overview Mus musculus BALB/c interleukin-18 + ?
-
?
pro-interleukin-1beta + H2O
-
Mus musculus interleukin-1beta + ?
-
?
pro-interleukin-1beta + H2O caspase-1 is essential for interleukin-1beta and interleukin-18 production in the eye in response to muramyl dipeptide. Activation of NOD2 results in IL-1beta production via a caspase-1-dependent mechanism, interleukin-1beta and caspase-1 contribute to muramyl dipeptide-induced ocular inflammation, overview Mus musculus interleukin-1beta + ?
-
?
pro-interleukin-1beta + H2O
-
Mus musculus BALB/c interleukin-1beta + ?
-
?
pro-interleukin-1beta + H2O caspase-1 is essential for interleukin-1beta and interleukin-18 production in the eye in response to muramyl dipeptide. Activation of NOD2 results in IL-1beta production via a caspase-1-dependent mechanism, interleukin-1beta and caspase-1 contribute to muramyl dipeptide-induced ocular inflammation, overview Mus musculus BALB/c interleukin-1beta + ?
-
?